Author/Authors :
Ferro، نويسنده , , M.T and V?zquez-Mazariego، نويسنده , , Y and Ramiro، نويسنده , , S and Santiago، نويسنده , , M.F and Garc??a-Sagredo، نويسنده , , J.M and Nu?ez، نويسنده , , R and Hern?ndez، نويسنده , , J.M. Ruiz-Roman، نويسنده , , C.San، نويسنده ,
Abstract :
We report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8.
