Author/Authors :
Katakowski، نويسنده , , Mark and Buller، نويسنده , , Ben-Xia Zheng، نويسنده , , Xuguang and Lu، نويسنده , , Yong and Rogers، نويسنده , , Thomas and Osobamiro، نويسنده , , Oyinkansola and Shu، نويسنده , , Wayne and Jiang، نويسنده , , Feng and Chopp، نويسنده , , Michael، نويسنده ,
Abstract :
Exosomes are 30–150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor.
Keywords :
Glioma , MicroRNA , Mesenchymal Stem Cell , miR-146b , Exosome
