Author/Authors :
Dal Cin، نويسنده , , Paola and Sciot، نويسنده , , Raf and Brys، نويسنده , , Peter and De Wever، نويسنده , , Ivo and Dorfman، نويسنده , , Howard and Fletcher، نويسنده , , Christopher D.M and Jonsson، نويسنده , , Kjell and Mandahl، نويسنده , , Nils and Mertens، نويسنده , , Fredrik and Mitelman، نويسنده , , Felix and Rosai، نويسنده , , Juan and Rydholm، نويسنده , , Anders and Samson، نويسنده , , Ignace and Tall، نويسنده ,
Abstract :
The nosologic status of fibrous dysplasia (FD), a well-known and relatively common bone lesion, is controversial. Information collected by the CHromosomes And MorPhology (CHAMP) study group on published and unpublished cases of fibrous dysplasia shows the presence of clonal chromosome changes in at least a proportion of these lesions. The chromosome aberrations found in FD lesions have been quite variable and have included both structural and numerical changes. Two of the three cases investigated at the study group had trisomy 2 as the sole acquired anomaly. Combined with previously published data, +2 and rearrangements involving chromosome band 12p13 have each been detected in 3 of 8 cases with abnormal karyotype of 11 in which chromosomal analysis has been performed, suggesting that FD is a neoplastic lesion rather than a “dysplastic” process, as has been generally believed and as implied by its very name.
