Author/Authors :
Nelson، نويسنده , , Mark A and Radmacher، نويسنده , , Michael D and Simon، نويسنده , , Richard and Aickin، نويسنده , , Mikel and Yang، نويسنده , , Jin-Ming and Panda، نويسنده , , Lita and Emerson، نويسنده , , Julia and Roe، نويسنده , , Denise and Adair، نويسنده , , Lawrence M. Thompson، نويسنده , , Floyd and Bangert، نويسنده , , Jerry and Leong، نويسنده , , Stanley P.L and Taetle، نويسنده , , Raymond and Sa، نويسنده ,
Abstract :
We report the cytogenetic abnormalities from a series of 206 primary malignant melanoma specimens referred to a single institution. A total of 169 out of 206 unique cases had chromosome breakpoints. A previously described statistical method was used to detect nonrandom distribution of chromosome breakpoints at the level of chromosome regions. Nonrandom occurrence of chromosome breakpoints (indicating that the observed number of breaks significantly exceeded the expected number of breaks) was detected in 28 regions, suggesting a hierarchy of genetic abnormalities in melanoma. Clinical variables and tumor characteristics were analyzed for associations with the presence of any nonrandom chromosome breakpoints; with individual, nonrandomly involved chromosome regions; and with paired, nonrandomly involved chromosome regions. No nonrandomly involved chromosome regions or pairs of regions appeared to significantly affect survival. These results identify recurring, nonrandom chromosome abnormalities in malignant melanoma. These results suggest that recurring, nonrandom chromosome alterations play a key role in the etiology and/or progression of malignant melanoma and identify targets within the genome for molecular genetic studies.
