Author/Authors :
Dou، نويسنده , , Ruoxu and Deng، نويسنده , , Yanhong and Huang، نويسنده , , Lanlan and Fu، نويسنده , , Shijun and Tan، نويسنده , , Shuyun and Wang، نويسنده , , Lei and Lian، نويسنده , , Lei and Fang، نويسنده , , Lekun and Fan، نويسنده , , Xinjuan and Jin، نويسنده , , Gang and Liu، نويسنده , , Huanliang and Wang، نويسنده , , Jianping، نويسنده ,
Abstract :
Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially expressed by at least two folds. AQP9, SATB2, and WIF1 were simultaneously lower expressed in the nonresponders and modulated by the differentially expressed miRNAs. RT-PCR validated the differential expression of AQP9 (p = 0.035). In conclusion, lower AQP9 gene expression is related with non-response to adjuvant chemotherapy, showing potential as predictive marker and therapeutic target.
