Author/Authors :
P Mezzelani، نويسنده , , Alessandra and Sozzi، نويسنده , , Gabriella and Nessling، نويسنده , , Michelle and Riva، نويسنده , , Carla and Della Torre، نويسنده , , Gabriella and Testi، نويسنده , , M.Adele and Azzarelli، نويسنده , , Alberto and Pierotti، نويسنده , , Marco A and Lichter، نويسنده , , Peter and Pilotti، نويسنده , , Silvana، نويسنده ,
Abstract :
Supernumerary rings in the context of a simple karyotype characterize several low-grade malignant tumors of soft tissue and bone. Low-grade fibromyxoid sarcoma is an uncommon low-grade sarcoma, the cytogenetics of which has not yet been reported. Here we describe the first molecular–cytogenetic characterization of a pulmonary metastasis of low-grade fibromyxoid sarcoma. The histology of the primary and recurrent tumors was consistent with the diagnosis of low-grade fibromyxoid sarcoma of the usual type, whereas the pulmonary metastasis was of the “giant rosettes” variant. Cytogenetic analysis revealed a ring chromosome. Because gain of material of chromosomes 7 and 16 was detected by CGH, the ring chromosome is assumed to be composed of material from these respective chromosomes.
