Author/Authors :
Zhou، نويسنده , , Shuangyuan and Liao، نويسنده , , Liqiu and Chen، نويسنده , , Chen and Zeng، نويسنده , , Weiqi and Liu، نويسنده , , Shuang and Su، نويسنده , , Juan and Zhao، نويسنده , , Shuang and Chen، نويسنده , , Mingliang and Kuang، نويسنده , , Yehong and Chen، نويسنده , , Xiang and Li، نويسنده , , Jie، نويسنده ,
Abstract :
CD147 and ABCG2 both have been reported to mediate Multidrug resistance (MDR) in breast cancer. Recent study demonstrates that CD147 could form a complex with ABCG2 on the cell membrane in primary effusion lymphoma. However, whether these two molecules regulate each other in breast cancer and result in MDR is not clear. We established four MCF-7 cell lines transfected with CD147 and/or ABCG2 and found that CD147 could increase the expression and dimerization of ABCG2, affect its cellular localization and regulate its drug transporter function. The findings derived from cells were confirmed subsequently in clinic samples of chemotherapy-sensitive/resistant breast cancer.
Keywords :
ABCG2 , Chemoresistance , CD147 , breast cancer
