Author/Authors :
Zattara-Cannoni، نويسنده , , H and Roll، نويسنده , , P and Figarella-Branger، نويسنده , , D and Lena، نويسنده , , G and Dufour، نويسنده , , H and Grisoli، نويسنده , , F and Vagner-Capodano، نويسنده , , A.-M، نويسنده ,
Abstract :
It is known that, following radiotherapy, secondary cancer may occur after a long latent period. Few cytogenetic studies have been reported on tumors of the central nervous system occurring after radiotherapy. We report the cytogenetic study of six cases of radiation-induced meningiomas. In all cases, we observed the same chromosome abnormality, der(1)(1qter→1p11::22q12→22pter). SKY and CGH techniques allowed us to identify the chromosomal abnormalities. We suggest that a gene localized on 1p13 is involved in radiation-induced meningiomas.
