Author/Authors :
Kiyozuka، نويسنده , , Yasuhiko and Nakagawa، نويسنده , , Hiroyuki and Uemura، نويسنده , , Yoshiko and Senzaki، نويسنده , , Hideto and Yamamoto، نويسنده , , Akitsugu and Noguchi، نويسنده , , Taketoshi and Mizuta، نويسنده , , Hirohisa and Nakanishi، نويسنده , , Kohji and Nakano، نويسنده , , Shiro and Tsubura، نويسنده , , Airo، نويسنده ,
Abstract :
Two cell lines (Nara-H and Nara-F) with different phenotypes were established from a myxoid MFH of the uterus. In vitro, Nara-F grew in sheets showing a storiform arrangement and Nara-H in raised colonies. Although tumors generated in nude mice shared similar morphological features of abundant myxoid tumor in Nara-H and -F, the pleomorphic component was conspicuous in Nara-F. Both cell lines produced hyaluronic-acid but CD44 was expressed only in Nara-H. Estrogen receptor α (ER α) and progesterone receptor (PgR) were detected in Nara-H. Nara-F was positive for ER β and PgR. Among hormonal agents, the response to the anti-estrogen tamoxifen was more sensitive than progesterone agents. This report illustrates the characteristics of these newly established cell lines, and presents the possibility of an adjuvant hormonal therapy for MFH.
