Author/Authors :
Goudarzi، نويسنده , , Houman and Iizasa، نويسنده , , Hisashi and Furuhashi، نويسنده , , Masako and Nakazawa، نويسنده , , Seitaro and Nakane، نويسنده , , Rie and Liang، نويسنده , , Shanshan and Hida، نويسنده , , Yasuhiro and Yanagihara، نويسنده , , Kazuyoshi and Kubo، نويسنده , , Takanori and Nakagawa، نويسنده , , Koji and Kobayashi، نويسنده , , Masanobu and Irimura، نويسنده , , Tatsuro and Hamada، نويسنده , , Jun-ichi، نويسنده ,
Abstract :
In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (1) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients.
Keywords :
Invasiveness , Mesothelioma , HIF , Hypoxia , MUC1 , Motility
