Author/Authors :
Li، نويسنده , , Yanyan and Wang، نويسنده , , Ying and Yu، نويسنده , , Lin and Sun، نويسنده , , Cuiyun and Cheng، نويسنده , , Degang and Yu، نويسنده , , Shizhu and Wang، نويسنده , , Qian and Yan، نويسنده , , Yaping and Kang، نويسنده , , Chunsheng and Jin، نويسنده , , Shumei and An، نويسنده , , Tongling and Shi، نويسنده , , Cuijuan and Xu، نويسنده , , Jinling and Wei، نويسنده , , Changjuan and Liu، نويسنده , , Jing and Sun، نويسنده , , Jing and Wen، نويسنده , , Yanjun and Zhao، نويسنده , , Shujun and Kong، نويسنده , , Yanling، نويسنده ,
Abstract :
miR-146b-5p is frequently down-regulated in solid tumours, including prostate cancer, pancreatic cancer, and glioblastoma. However, the tumour-suppressive effects of miR-146b-5p in malignant gliomas have not been investigated thoroughly. Here, we found that decreased miR-146b-5p expression was strongly correlated with chromosome 10q loss in gliomas, especially glioblastomas. The overexpression of miR-146b-5p in glioblastoma cell lines led to MMP16 mRNA silencing, MMP2 inactivation, and the inhibition of tumour cell migration and invasion. Our results suggest that the restoration of miR-146b-5p expression may be a feasible approach for inhibiting the migration and invasion of malignant gliomas.
Keywords :
Gliomas , MIGRATION , Invasion , miR-146b-5p , MMP16
