Author/Authors :
Deng، نويسنده , , Yujie and Huang، نويسنده , , Zhenxia and Xu، نويسنده , , Yanjun and Jin، نويسنده , , Juan and Zhuo، نويسنده , , Wei and Zhang، نويسنده , , Cheng and Zhang، نويسنده , , Xuting and Shen، نويسنده , , Minhong and Yan، نويسنده , , Xiaoyi and Wang، نويسنده , , Liangjing and Wang، نويسنده , , Xiaojia and Kang، نويسنده , , Yibin and Si، نويسنده , , Jianmin and Zhou، نويسنده , , Tianhua، نويسنده ,
Abstract :
Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3′-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.
Keywords :
MiR-215 , retinoblastoma , Proliferation , Gastric cancer
