Author/Authors :
Granzow، نويسنده , , Martin and Popp، نويسنده , , Susanne and Weber، نويسنده , , Susanne and Schoell، نويسنده , , Brigitte and Holtgreve-Grez، نويسنده , , Heidi and Senf، نويسنده , , Leonore and Hager، نويسنده , , Dieter and Boschert، نويسنده , , Jürgen and Scheurlen، نويسنده , , Wolfram and Jauch، نويسنده , , Anna، نويسنده ,
Abstract :
Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of 1q corresponding to an isochromosome 1q was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma.
