Author/Authors :
Zhang، نويسنده , , Fang and Yang، نويسنده , , Zhiping and Cao، نويسنده , , Minjun and Xu، نويسنده , , Yinsheng and Li، نويسنده , , Jintao and Chen، نويسنده , , Xuebin and Gao، نويسنده , , Zhi-Jun Xin، نويسنده , , Jing and Zhou، نويسنده , , Shaomei and Zhou، نويسنده , , Zhixiang and Yang، نويسنده , , Yishu and Sheng، نويسنده , , Qiu-wang and Zeng، نويسنده , , Yi، نويسنده ,
Abstract :
The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21.
Keywords :
Esophageal cancer , miR-203 , Tumor suppressor , miR-21 , RAN
