Title of article :
Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies
Author/Authors :
Zhou، نويسنده , , Qianjun and Facciponte، نويسنده , , John and Jin، نويسنده , , Min and Shen، نويسنده , , Qiang and Lin، نويسنده , , Qiang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg–/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg–/– mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.
Keywords :
Xenograft , Tumor Model , Preclinical model , Humanized mice , Immunodeficient mice , NOD-SCID-IL2rg–/– mice
Journal title :
Cancer Letters
Journal title :
Cancer Letters
