Author/Authors :
Lee، نويسنده , , Francis Young-In and Zawadsky، نويسنده , , Mark and Parisien، نويسنده , , May and Ho، نويسنده , , Mike and Murty، نويسنده , , Vundavalli V.V.S. and Jayaraman، نويسنده , , Thottala and Dick، نويسنده , , Harold M.، نويسنده ,
Abstract :
We report a new translocation in a patient with a history of hereditary multiple exostosis (HME) who developed a recurrent grade I chondrosarcoma involving the sacrum and retroperitoneum. Karyotypic analysis of the tumor revealed a sole chromosome abnormality t(9;12)(q22;q24.3). To our knowledge, this translocation has not been previously identified in either chondrosarcoma, HME, or related tumor types. Our novel translocation may be related to the sarcomatous degeneration of the pre-existing exostosis.
