Author/Authors :
Moelans، نويسنده , , Cathy B. and van der Groep، نويسنده , , Petra and Hoefnagel، نويسنده , , Laurien D.C. and van de Vijver، نويسنده , , Marc J. and Wesseling، نويسنده , , Pieter and Wesseling، نويسنده , , Jelle and van der Wall، نويسنده , , Elsken and van Diest، نويسنده , , Paul J.، نويسنده ,
Abstract :
Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.
Keywords :
breast cancer , MLPA , Metastases , Gene dosage
