Author/Authors :
Ishida، نويسنده , , Fumihiro and Ueno، نويسنده , , Mayumi and Tanaka، نويسنده , , Hitoshi and Makishima، نويسنده , , Hideki and Suzawa، نويسنده , , Kenichi and Hosaka، نويسنده , , Shigetoshi and Hidaka، نويسنده , , Eiko and Ishikawa، نويسنده , , Masayo and Yamauchi، نويسنده , , Kazuyoshi and Kitano، نويسنده , , Kiyoshi and Kiyosawa، نويسنده , , Kendo Kiyosawa، نويسنده ,
Abstract :
We report a male patient with acute myelogenous leukemia (AML; French–American–British M2) associated with AML1-ETO. Cytogenetic studies showed a complex karyotype including a novel translocation (8;21;14)(q22;q22;q24) in all analyzed cells. This three-way translocation was confirmed with spectral karyotyping. Reverse transcription–polymerase chain reaction analysis for AML1-ETO chimeric transcripts showed the presence of the fusion product with the expected size. Translocation (8;21;14)(q22;q22;q24) is a novel variant of t(8;21)(q22;q22), possibly having a common molecular pathogenetic mechanism.
