Author/Authors :
O’Connor، نويسنده , , Michael L. and Xiang، نويسنده , , Dongxi and Shigdar، نويسنده , , Sarah and Macdonald، نويسنده , , Joanna and Li، نويسنده , , Yong and Wang، نويسنده , , Tao and Pu، نويسنده , , Chunwen and Wang، نويسنده , , Zhidong and Qiao، نويسنده , , Liang and Duan، نويسنده , , Wei، نويسنده ,
Abstract :
Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
Keywords :
Cancer stem cells , Chemoresistance , Clonal evolution , Aptamers , Stemness
