Author/Authors :
Déborah Afonso and Schmid-Braz، نويسنده , , Ana Teresa and Cavalli، نويسنده , , Luciane Regina and Cornélio، نويسنده , , Déborah Afonso and Wuicik، نويسنده , , Lismeri and Ribeiro، نويسنده , , Enilze M.S.F. and Bleggi-Torres، نويسنده , , Luiz F. and Lima، نويسنده , , Rubens Silveira and de Andrade Urban، نويسنده , , C??cero and Haddad، نويسنده , , Bassem R. and Cavalli، نويسنده , , Iglenir J، نويسنده ,
Abstract :
Mature ovarian teratomas are benign ovarian germ cell tumors that usually present with a normal karyotype. There are very few reports describing chromosomal abnormalities in these tumors, none of which are recurrent. In this study we report on a mature teratoma case with clonal chromosomal alterations which include monosomies of chromosomes 6, 14, 16, and 21; trisomies of chromosomes 14 and 21; and deletions of Xq, 5p, 16p, and 17p. Comparative genomic hybridization evaluation of the sample revealed a normal profile. These findings are discussed together with the cytogenetic reports on other cases of ovarian teratomas described in the literature.
