Author/Authors :
Shen، نويسنده , , Qingyu and Bae، نويسنده , , Hyun Jin and Eun، نويسنده , , Jung Woo and Kim، نويسنده , , Hyung Seok and Park، نويسنده , , Se Jin and Shin، نويسنده , , Woo Chan and Lee، نويسنده , , Eun Kyung and Park، نويسنده , , Soha and Park، نويسنده , , Won-Sang and Lee، نويسنده , , Jung Young and Nam، نويسنده , , Suk Woo، نويسنده ,
Abstract :
Nemo-like kinase (NLK), an evolutionarily conserved MAP kinase-related kinase, has been reported to be involved in the development of hepatocellular carcinoma (HCC), but the underlying mechanisms leading to oncogenic NLK are poorly understood. A comprehensive microRNA (miRNA) profiling analysis on human HCC tissues identified four downregulated miRNAs that may target NLK. Ectopic expression of miRNA mimics suggested that miR-101 could suppress NLK in HCC cells. Notably, ectopic miR-101 expression repressed cancer cell growth and proliferation and imitated NLK knockdown effect on HCC cells. In conclusion, we suggest that miR-101 functions as a tumor suppressor by regulating abnormal NLK activity in liver.
Keywords :
Tumor suppressor , NLK , Liver Cancer , MiR-101
