Title of article :
New cytogenetic variant, insertion (15;17)(q22;q12q21), in an adolescent with acute promyelocytic leukemia
Author/Authors :
Rolston، نويسنده , , Raj and Weck، نويسنده , , Karen E. and Tersak، نويسنده , , Jean M. and Sherer، نويسنده , , Maureen E. and Cumbie، نويسنده , , Kathleen and Shekhter-Levin، نويسنده , , Sofia، نويسنده ,
Abstract :
We present the case of a 15-year-old female with acute promyelocytic leukemia and a new variant chromosome rearrangement identified as ins(15;17)(q22;q12q21) by conventional cytogenetic analysis. This finding was confirmed by fluorescence in situ hybridization using the PML-RARA DNA probe and whole chromosome paints 15 and 17. A typical PML-RARA fusion transcript consistent with a breakpoint in intron 3 of the PML gene and intron 2 of the RARA gene was identified by reverse transcription polymerase chain reaction.
