Title of article
Dickkopf-1 as a mediator and novel target in malignant bone disease
Author/Authors
Rachner، نويسنده , , Tilman D. and Gِbel، نويسنده , , Andy and Benad-Mehner، نويسنده , , Peggy and Hofbauer، نويسنده , , Lorenz C. and Rauner، نويسنده , , Martina، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
6
From page
172
To page
177
Abstract
Bone metastases are a common problem of many malignancies, including myeloma, breast and prostate cancer. The Wnt inhibitor Dickkopf-1 has been shown to be involved in the process of bone lesions by impairing osteoblast activity. This review will focus on the role of Dickkopf-1 as a mediator of malignant bone disease and discuss its potential as a novel therapeutic target.
Keywords
WNT SIGNALING , Malignant bone disease , Dickkopf-1
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1824465
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