Author/Authors :
Lei، نويسنده , , Jianjun and Huo، نويسنده , , Xiongwei and Duan، نويسنده , , Wanxing and Xu، نويسنده , , Qinhong and Li، نويسنده , , Rong and Ma، نويسنده , , Jiguang and Li، نويسنده , , Xuqi and Han، نويسنده , , Liang and Li، نويسنده , , Wei and Sun، نويسنده , , Hao and Wu، نويسنده , , Erxi and Ma، نويسنده , , Qingyong، نويسنده ,
Abstract :
Recent advances indicating a key role of microenvironment for tumor progression, we investigated the role of PSCs and hypoxia in pancreatic cancer aggressiveness, and examined the potential protective effect of α-mangostin on hypoxia-driven pancreatic cancer progression. Our data indicate that hypoxic PSCs exploit their oxidative stress due to hypoxia to secrete soluble factors favouring pancreatic cancer invasion. α-Mangostin suppresses hypoxia-induced PSC activation and pancreatic cancer cell invasion through the inhibition of HIF-1α stabilization and GLI1 expression. Increased generation of hypoxic ROS is responsible for HIF-1α stabilization and GLI1 upregulation. Therefore, α-mangostin may be beneficial in preventing hypoxia-induced pancreatic cancer progression.
Keywords :
?-mangostin , Hypoxia , PSC , ROS , pancreatic cancer
