Title of article :
Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer
Author/Authors :
Feng، نويسنده , , Wan and Zhang، نويسنده , , Bin and Cai، نويسنده , , Dawei and Zou، نويسنده , , Xiaoping، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
8
From page :
183
To page :
190
Abstract :
Pancreatic cancer is a devastating disease with a dismal prognosis. Surgical resection is the only curative option but is heavily hampered by delayed diagnosis. Due to few therapeutic treatments available, novel and efficacious therapy is urgently needed. Histone deacetylase inhibitors (HDACIs) are emerging as a prominent class of therapeutic agents for pancreatic cancer and have exhibited significant anticancer potential with negligible toxicity in preclinical studies. Clinical evaluations of HDACIs are currently underway. HDACIs as monotherapy in solid tumors have proven less effective than hematological malignancies, the combination of HDACIs with other anticancer agents have been assessed for advanced pancreatic cancer. In this review, we describe the molecular mechanism underpin the anticancer effect of HDACIs in pancreatic cancer and summarize the recent advances in the rationale for the combination strategies incorporating HDACIs. In addition, we discuss the importance of identifying predictors of response to HDACI-based therapy.
Keywords :
Histone deacetylases , pancreatic cancer , HDAC inhibitors , combination therapy
Journal title :
Cancer Letters
Serial Year :
2014
Journal title :
Cancer Letters
Record number :
1824608
Link To Document :
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