Author/Authors :
Chen، نويسنده , , Ming-Cheng and Lee، نويسنده , , Nien-Hung and Ho، نويسنده , , Tsung-Jung and Hsu، نويسنده , , Hsi-Hsien and Kuo، نويسنده , , Chia-Hua and Kuo، نويسنده , , Wei-Wen and Lin، نويسنده , , Yueh-Min and Tsai، نويسنده , , Fuu-Jen and Tsai، نويسنده , , Chang-Hai and Huang، نويسنده , , Chih-Yang، نويسنده ,
Abstract :
Chemotherapy is usually applied to treat colon cancer but leads to chemoresistance, and increased metastasis and invasion. The main focus of this study is to observe effects of resistance to irinotecan (CPT-11) on metastasis, invasion and autophagy in CPT-11 resistant (CPT-11-R) LoVo colon cancer cells. CPT-11, a topoisomerase I inhibitor and a first-line chemotherapeutic drug, is used to treat colon cancer. CPT-11-R cells were constructed in a step-wise fashion with increasing CPT-11 doses. The CPT-11-R strain had a significantly lower expression of Wnt/β-catenin pathway, but induced an EGFR/IKKα/β/NF-κB pathway with elevated cell cycle, metastasis and basal autophagy.
Keywords :
metastasis , Autophagy , CPT-11 , Chemoresistance , NF-?B
