Author/Authors :
Gomez-Martيn، نويسنده , , Carlos and Lopez-Rios، نويسنده , , Fernando and Aparicio، نويسنده , , Jorge and Barriuso، نويسنده , , Jorge and Garcيa-Carbonero، نويسنده , , Rocio and Pazo، نويسنده , , Roberto Cedillo-Rivera، نويسنده , , Fernando and Salgado، نويسنده , , Mercedes and Salud، نويسنده , , Antonieta and Vلzquez-Sequeiros، نويسنده , , Enrique and Lordick، نويسنده , , Florian، نويسنده ,
Abstract :
Identification of the importance of human epidermal growth factor receptor-2 (HER2) status, biomarker testing and the development of anti-HER2 treatments have changed the prognosis of breast and gastric cancers. The addition of trastuzumab to chemotherapy has improved outcomes for patients with HER2-positive metastatic adenocarcinoma of the stomach and gastroesophageal junction, but some relevant issues remain to be elucidated or will emerge with new drugs. This article reviews the current state of HER2 in gastric cancer focusing on diagnostic and anti-HER2 targeted treatment issues and the role of trastuzumab in localized disease, and its combination or integration with new therapies.
Keywords :
Review , HER2 , Gastric cancer , Trastuzumab
