Author/Authors :
Sawyer، نويسنده , , Jeffrey R. and Thomas، نويسنده , , Edward L. and Lukacs، نويسنده , , Janet L. and Swanson، نويسنده , , Charles M. and Ding، نويسنده , , Yiling and Parham، نويسنده , , David M. and Thomas، نويسنده , , James R. and Nicholas، نويسنده , , Richard W.، نويسنده ,
Abstract :
Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors. Surprisingly, three of the chromosome 1 aberrations involved pericentric inversions. Four tumors showed aberrations involving the region 1p13∼p22 by mechanisms including inversion, insertion, and translocation. These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13∼p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
