Title of article
FOXC2 promotes colorectal cancer proliferation through inhibition of FOXO3a and activation of MAPK and AKT signaling pathways
Author/Authors
Cui، نويسنده , , Yan-Mei and Jiang، نويسنده , , Dan and Zhang، نويسنده , , Shi-Hong and Wu، نويسنده , , Ping and Ye، نويسنده , , Yaping and Chen، نويسنده , , Cui-Min and Tang، نويسنده , , Na and Liang، نويسنده , , Li and Li، نويسنده , , Ting-Ting and Qi، نويسنده , , Lu and Wang، نويسنده , , Shu-Yang and Jiao، نويسنده , , Hong-Li and Lin، نويسنده , , Jie and Ding، نويسنده , , Yan-Qing and Liao، نويسنده , , Wen-Ting، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
8
From page
87
To page
94
Abstract
Abnormal expression of FOXC2 has been found in several human cancers. However, the role of FOXC2 in the progression of colorectal cancer (CRC) has not been well characterized. In analysis of 206 CRC specimens, we revealed that both high expression and nuclear localization of FOXC2 were correlated to aggressive characteristics and poor survival of patients with CRC. FOXC2 promoted cell proliferation through activation of MAPK and AKT pathways, subsequently down-regulating p27, up-regulating cyclin D1 and p-FOXO3a. Furthermore, FOXC2 nuclear localization was required for its promotion of cell proliferation. These findings suggest that FOXC2 plays an essential role in CRC progression and may serve as a valuable clinical prognostic marker of this disease.
Keywords
FOXC2 , Colorectal Cancer , Prognosis , Nuclear localization , Proliferation
Journal title
Cancer Letters
Serial Year
2014
Journal title
Cancer Letters
Record number
1825001
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