Waldenstrِm macroglobulinemia with a novel der(8;17)(q10;q10)

We report the occurrence of an unbalanced whole-arm translocation of der(8;17)(q10;q10) in an 80-year-old female patient with Waldenstrِm macroglobulinemia. To our knowledge, der(8;17)(q10;q10) has not been described in Waldenstrِm macroglobulinemia. Although this cytogenetic abnormality has been reported in a number of solid tumors, a literature review suggests also a possible association with B-cell chronic lymphoproliferative disorders.