Author/Authors :
Heintel، نويسنده , , Daniel and Streubel، نويسنده , , Berthold and Welzel، نويسنده , , Natascha and Le، نويسنده , , Trang and Schwarzinger، نويسنده , , Ilse and Haas، نويسنده , , Oskar A. and Simonitsch، نويسنده , , Ingrid and Lechner، نويسنده , , Klaus and Jaeger، نويسنده , , Ulrich، نويسنده ,
Abstract :
We report the progression of splenic marginal zone lymphoma (SMZL) with circulating villous lymphocytes to Burkitt lymphoma with the presence of a t(8;14)(q24;q32) followed by a highly aggressive course. While the initial indolent lymphoma had an IgM λ immunophenotype the Burkitt lymphoma was IgM κ-positive. Immunoglobulin heavy chain gene (IGH) sequence analysis showed no identity between the two clones. We conclude that Burkitt lymphoma can occur in patients with SMZL, although not necessarily of identical clonal origin.
