Author/Authors :
Zhang، نويسنده , , Li Feng and Tan، نويسنده , , Darren Qian Cheng and Jeyasekharan، نويسنده , , Anand D. and Hsieh، نويسنده , , Wen Son and Ho، نويسنده , , Anh Son and Ichiyama، نويسنده , , Koji and Ye، نويسنده , , Min and Pang، نويسنده , , Brendan and Ohba، نويسنده , , Kenji and Liu، نويسنده , , Xin and de Mel، نويسنده , , Sanjay and Cuong، نويسنده , , Bui Khac and Chng، نويسنده , , Wee Joo and Ryo، نويسنده , , Akihide and Suzuki، نويسنده , , Youichi and Yeoh، نويسنده , , Khay Guan and Toan، نويسنده , , Nguyen Linh and Yamamoto، نويسنده , , Naoki، نويسنده ,
Abstract :
Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.
Keywords :
Mumps virus , Acute Myeloid Leukemia , Measles virus , Oncolytic virus
