Author/Authors :
Gao، نويسنده , , Huijie and Peng، نويسنده , , Cheng and Liang، نويسنده , , Benjia and Shahbaz، نويسنده , , Muhammad and Liu، نويسنده , , Song and Wang، نويسنده , , Ben-hui Sun، نويسنده , , Qi and Niu، نويسنده , , Zhengchuan and Niu، نويسنده , , Weibo and Liu، نويسنده , , Enyu and Wang، نويسنده , , Jiayong and Lin، نويسنده , , Pengfei and Wang، نويسنده , , Jian-Jin Niu، نويسنده , , Jun، نويسنده ,
Abstract :
We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.
