Author/Authors :
Okazaki، نويسنده , , Mitsuyoshi and Fushida، نويسنده , , Sachio and Harada، نويسنده , , Shinichi and Tsukada، نويسنده , , Tomoya and Kinoshita، نويسنده , , Jun-ichi Oyama، نويسنده , , Katsunobu and Tajima، نويسنده , , Hidehiro and Ninomiya، نويسنده , , Itasu and Fujimura، نويسنده , , Takashi and Ohta، نويسنده , , Tetsuo، نويسنده ,
Abstract :
Gastric cancer with peritoneal dissemination has poor clinical prognosis because of the presence of rich stromal fibrosis and acquired drug resistance. Recently, Angiotensin II type I receptor blockers such as candesartan have attracted attention for their potential anti-fibrotic activity. We examined whether candesartan could attenuate tumor proliferation and fibrosis through the interaction between gastric cancer cell line (MKN45) cells and human peritoneal mesothelial cells. Candesartan significantly reduced TGF-β1 expression and epithelial-to-mesenchymal transition-like change, while tumor proliferation and stromal fibrosis were impaired. Targeting the Angiotensin II signaling pathway may therefore be an efficient strategy for treatment of tumor proliferation and fibrosis.
Keywords :
angiotensin II , Gastric cancer , Fibrosis , Peritoneal dissemination , TGF-?
