Author/Authors :
A. Jarosova، نويسنده , , M and Holzerov?، نويسنده , , M and Mih?l، نويسنده , , V and Lakom?، نويسنده , , I and Divok?، نويسنده , , V and Bla?ek، نويسنده , , B and Posp???ilov?، نويسنده , , D and Hajd?ch، نويسنده , , M and Nov?k، نويسنده , , Z and Du?ek، نويسنده , , L and Kopt??kov?، نويسنده , , J and Poulsen، نويسنده , , T.S and Indr?k، نويسنده , , K، نويسنده ,
Abstract :
Cytogenetic and molecular cytogenetic analysis of 79 childhood acute lymphoblastic leukemias (ALL) revealed chromosomal abnormalities in 76 (96%). Complex karyotypes (a finding of three and more chromosomal aberrations in a karyotype) were identified in 21 (26.6%) out of 79 patients. In 11 patients, complex karyotypes have included common recurrent chromosomal abnormalities, such as translocation t(12;21) in seven cases, t(9;22) in two cases, one case with t(2;1;19) and another one with translocation involving 11q23. In 10 patients, miscellaneous abnormalities were detected. Five patients displayed hyperdiploidy (47∼57 chromosomes), three patients complex karyotypes with deletions of 9p, one patient with two new complex translocations t(2;4;12;13) and t(7;11;20), and the last patient with dic(12;21). The evaluation of the frequency of the chromosomal breaks (>5 per chromosome) showed that chromosomes 2, 4, 5, 7, 9, 12, 13, and 21 were most frequently affected. Survival analysis revealed statistically significant unfavorable event-free survival (EFS) (P = 0.013) and decreased overall survival in the group with complex karyotypes (n = 21) compared with the other cases (n = 58). The evaluation of overexpression profile revealed increased occurrence of double CD13/CD33 positivity in patients with common recurrent chromosomal abnormalities (in 70% of cases); no such cases were registered in the other group (P<0.01).
