The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk

We evaluated the association between the XPD exon 10 Asp312Asn and exon 23 Lys751Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn312Asn genotype had a significantly reduced risk when compared with those carrying the 312Asp allele (OR=0.46, 95% confidence interval 0.24–0.88) (P for interaction=0.03). The 312Asp–751Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.