Author/Authors :
Morerio، نويسنده , , Cristina and Rapella، نويسنده , , Annamaria and Rosanda، نويسنده , , Cristina and Lanino، نويسنده , , Edoardo and Lo Nigro، نويسنده , , Luca and Di Cataldo، نويسنده , , Andrea and Maserati، نويسنده , , Emanuela and Pasquali، نويسنده , , Francesco and Panarello، نويسنده , , Claudio، نويسنده ,
Abstract :
Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French–American–British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
