Author/Authors :
Clendenen، نويسنده , , Tess V. and Arslan، نويسنده , , Alan A. and Koenig، نويسنده , , Karen L. and Enquist، نويسنده , , Kerstin and Wirgin، نويسنده , , Isaac and إgren، نويسنده , , إsa and Lukanova، نويسنده , , Annekatrin and Sjodin، نويسنده , , Hubert and Zeleniuch-Jacquotte، نويسنده , , Anne and Shore، نويسنده , , Roy E. and Hallmans، نويسنده , , Gِran and Toniolo، نويسنده , , Paolo and Lundin، نويسنده , , Eva، نويسنده ,
Abstract :
The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population.
Keywords :
Vitamin D receptor , Prospective cohorts , Epidemiology , Genetic variants , Ovarian Neoplasms
