Title of article :
Translocation (16;18)(p13;q21.3) in follicular lymphoma
Author/Authors :
Mahmoodi، نويسنده , , Mandana and Tanev، نويسنده , , Silvio S. and Punnett، نويسنده , , Hope H. and Crilley، نويسنده , , Pamela and Hou، نويسنده , , J. Steve، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
We describe a novel t(16;18)(p13;q21.3) in a male patient with follicular lymphoma. This unique chromosomal rearrangement has never been described in patients with follicular lymphoma. The breakpoint of 16p13 has several hematopoietic neoplasm-related genes such as MHC2TA, a master regulatory gene for HLA-D, and BCMA, tumor necrosis factor receptor super-family. The majority of follicular lymphomas have a rearrangement of the BCL2 gene, which is a pathogenetic factor in their development. The diagnostic and prognostic significance of this new translocation is yet to be determined.
Journal title :
Cancer Genetics and Cytogenetics
Journal title :
Cancer Genetics and Cytogenetics
