Title of article
Molecular cytogenetic study of instability at 1q21∼q32 in adult acute lymphoblastic leukemia
Author/Authors
Specchia، نويسنده , , Giorgina and Albano، نويسنده , , Francesco and Anelli، نويسنده , , Luisa and Zagaria، نويسنده , , Antonella and Liso، نويسنده , , Arcangelo and Pannunzio، نويسنده , , Alessandra and Archidiacono، نويسنده , , Nicoletta and Liso، نويسنده , , Vincenzo and Rocchi، نويسنده , , Mariano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
54
To page
58
Abstract
In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2005
Journal title
Cancer Genetics and Cytogenetics
Record number
1826457
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