Author/Authors :
Gill، نويسنده , , Harvindar Kaur and Keoh، نويسنده , , Ten Sew and Dhaliwal، نويسنده , , Jasbir Singh and Moore، نويسنده , , Sarah and Kim، نويسنده , , Tan Sew and Hassan، نويسنده , , Roshida and Karim، نويسنده , , Faraiza Abdul and Zakaria، نويسنده , , Zubaidah and Murad، نويسنده , , Shahnaz and Mohamed، نويسنده , , Mahfuzah and Li Ho، نويسنده , , Caroline Mei and Ibrahim، نويسنده , , Hishamshah، نويسنده ,
Abstract :
Eighty-eight multi-ethnic Malaysian pediatric acute lymphoblastic leukemia (ALL) patients were screened for the TEL-AML1 rearrangement by reverse transcription-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was used as an independent screen for 30 cases and to confirm RT-PCR positive cases. Seventeen patients, or 19%, were found to be t(12;21) positive. Ethnically the group comprised 12 Malays, 4 Chinese, and 1 Indian. All patients, including 1 with an unusual blast cell morphology who suffered an early relapse and death, were characteristic TEL-AML1 cases in cell count, age, ALL subset classification, and fusion transcript expressed. This study shows that in Malaysia, TEL-AML1 is found in the same distinct ALL subset and at a similar frequency as in other diverse childhood ALL cohorts.
