A clonal dic(16;21)(p13.1;p11.2)del(16)(q11.1), with gains of several chromosomes and monosomy 21, in a case of splenic hamartoma: evidence for its neoplastic, not hamartomatous, origin

Cytogenetic examination of a case of splenic hamartoma led to the discovery of a clonal population with the karyotype 47∼58,XX,+X,+4,+5,+5,+6,+10,+12,+14,der(16)dic(16;21)(p13.3;p11.2), dic(16;21)del(16)(q11.1),+17,+19,+20,−21. This finding is indicative of a neoplastic, not hamartomatous, origin for this lesion.