Title of article :
Cryptic MLL-AF10 fusion caused by insertion of duplicated 5′ part of MLL into 10p12 in acute leukemia: a case report
Author/Authors :
A. Jarosova، نويسنده , , Marie and Takacova، نويسنده , , Sylvia and Holzerova، نويسنده , , Milena and Priwitzerova، نويسنده , , Monika and Divoka، نويسنده , , Martina and Lakoma، نويسنده , , Ilona and Mihal، نويسنده , , Vladimir and Indrak، نويسنده , , Karel and Divoky، نويسنده , , Vladimir، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
4
From page :
179
To page :
182
Abstract :
Chromosomal translocations involving the mixed lineage leukemia gene (MLL) located at 11q23 belong to common chromosomal abnormalities in both acute lymphoblastic (ALL) and acute myeloid leukemias (AML). It has been suggested that the mechanism of MLL leukemogenesis might be a result of a gain-of-function effect of the MLL fusion gene and simultaneous loss of function of one of the MLL alleles (haploinsufficiency). One of the recurrent translocations in AML-M5 involves chromosomal locus 10p12 and results in the MLL-AF10 fusion gene. Several mechanisms leading to MLL-AF10 fusion have been reported, and they have involved rearrangement of the 11q23 region. We present a detailed structural analysis of an AML case with an extra copy of the 5′ part of MLL region and its insertion into the short arm of chromosome 10, resulting in an MLL-AF10 fusion without rearrangement of the MLL alleles on both chromosomes 11. Our observation supports a role for a simple MLL gain-of-function in leukemogenesis.
Journal title :
Cancer Genetics and Cytogenetics
Serial Year :
2005
Journal title :
Cancer Genetics and Cytogenetics
Record number :
1827113
Link To Document :
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