Author/Authors :
Mihaela Jekic، نويسنده , , Biljana and Novakovic، نويسنده , , Ivana and Lukovic، نويسنده , , Ljiljana and Kuzmanovic، نويسنده , , Milos R. Popovic، نويسنده , , Branka and Milasin، نويسنده , , Jelena and Bunjevacki، نويسنده , , Gordana and Damnjanovic، نويسنده , , Tatjana and Cvjeticanin، نويسنده , , Suzana and Bunjevacki، نويسنده , , Vera، نويسنده ,
Abstract :
Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5–9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.
