Author/Authors :
Olshanskaya، نويسنده , , Yulia V. and Udovichenko، نويسنده , , Alla I. and Vodinskaya، نويسنده , , Lubov A. and Glasko، نويسنده , , Eugenia N. and Parovitchnikova، نويسنده , , Elena N. and Lorie، نويسنده , , Yurii Yu. and Dvirnik، نويسنده , , Valentina N. and Savchenko، نويسنده , , Valerii G. and Domracheva، نويسنده , , Elena V.، نويسنده ,
Abstract :
Deletions of Xq are extremely rare events in myelodysplastic syndromes (MDS) patients and were previously described in five patients, in two of them as a sole chromosome abnormality. We found isolated del(Xq) in 3 of 127 MDS patients with clonal chromosome changes. Detailed analysis of clinical and morphological data of presented and previously published cases indicates the following: (1) del(X)(q24) and del(X)(q13) are nonrandom chromosomal abnormalities in MDS; (2) MDS with deletions of Xq affect exclusively females ages 46–65; and (3) deletions of Xq are associated with refractory anemia with excess blasts (RAEB) and indicate an unfavorable prognosis.
