Author/Authors :
Kabade، Sarina P نويسنده Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore-560001. , , J.C، Savinay Kumar نويسنده Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore-560001. , , C V، Harish Kumar نويسنده Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore-560001. , , K.C، SurendraBabu نويسنده Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore-560001. , , J V، Abhinava نويسنده Department of PG Studies and Research in Biotechnology, Government Science College, Bangalore-560001. , , R، Guruprasad نويسنده DurgaFemto Technologies and Research, Chamarajpet, Bangalore-560018 ,
Abstract :
The angiotensin converting enzyme (ACE) plays a vital role in regulating the blood pressure. The activity of ACE was screened between the eye and the heart of the zebrafish, by using hippuryl-L-histidyl-L-leusin as a substrate. Among these zebrafish eyes shows maximum activity. The screening of ACE activator is done from different plant methanol extract such as Salviniamolesta, Murrayakoenigii, Lantana camara & Eucalyptus oblique. Among these plants Lantanacamar a shows maximum ACE activity. The GC-MS analysis of Lantana camara detects 21 different compounds whereas cis-9-Octadecenal (19.8%), Squalene (19%), Hexadecanoic acid (17%) are in high concentration. All 21 compounds were subjected to the docking studies with an ACE enzyme using the software auto dock. Among these compounds Stigmast-5-en-ololeat shows maximum affinity towards the enzyme and this compound can be used as a potent ACE activator.
