SMALL DENSE LDL–A BETTER PREDICTOR FOR CORONARY HEART DISEASE

The LDL subfraction i.e. small dense LDL is more atherogenic form of the LDL and is observed as an important risk factor for coronary heart disease. A preponderance of small dense LDL is associated with a 3-7 fold increase in CHD risk. In this study we aimed to find out whether small dense LDL is a better predictor of coronary heart disease than LDL and other lipid parameters. The present study comprised of thirty clinically diagnosed cases of CHD admitted in ICU of J.A. group of hospital and thirty age and sex matched healthy individuals were considered as control subjects. These patients were investigated for lipid profile and small dense LDL on the first day of their admission in ICU. There was a significant change in lipid profile and small dense LDL in the study group compared to controls. There was a significant positive correlation between small dense LDL and triglycerides. These results suggest that high small dense LDL concentration is more potent risk factor for CHD in comparison to other lipid and lipoproteins.