Author/Authors :
Lee، نويسنده , , Su Jeong and Kim، نويسنده , , Kyung Mee and Chae، نويسنده , , Myung Hwa and Lee، نويسنده , , Won Kee and Kam، نويسنده , , Sin and Cha، نويسنده , , Sung Ick and Han، نويسنده , , Hyung Soo and Kim، نويسنده , , Chang Ho and Kang، نويسنده , , Young Mo and Han، نويسنده , , Sung Beom and Park، نويسنده , , Jae Yong، نويسنده ,
Abstract :
The tyrosine kinase receptor EGFR pathway is one of the oncogenic signaling cascades involved in lung cancer, mediating the epidermal growth factor receptor gene EGFR. First-intron polymorphisms with greater numbers of CA dinucleotide repeats tend to downregulate EGFR expression, which suggests that this polymorphism may modulate susceptibility to lung cancer. The present hospital-based case–control study evaluated the possible association of CA repeat polymorphism in the EGFR gene with risk of lung cancer in a Korean population. A bimodal pattern appeared, with a frequency of 57.1% for 20 CA repeats and 18.6% for 16 CA repeats. There was, however, no significant difference in distribution of allele genotypes between all lung cancer cases and the controls, nor among histological types for the cases.
