Author/Authors :
Vauleon، نويسنده , , Elodie and Auger، نويسنده , , Nathalie and Benouaich-Amiel، نويسنده , , Alexandra and Laigle-Donadey، نويسنده , , Florence and Kaloshi، نويسنده , , Gentian and Lejeune، نويسنده , , Julie and Delattre، نويسنده , , Jean-Yves and Thillet، نويسنده , , Joëlle and Sanson، نويسنده , , Marc، نويسنده ,
Abstract :
The A/G61 polymorphism located in the 5′UTR of the EGF gene has been found to be both a risk factor and a prognostic factor in glioblastoma (GBM), but the functional consequences have not been investigated. Here we show, in vitro, that this polymorphism is functional, in that the G allele promoter is 40% more active than the A variant (P < 0.001). However, analysis of a large series of 209 GBM patients and 214 control subjects did not confirm that A/G61 polymorphism is a significant risk factor for GBM, despite a trend for higher GG frequency in these patients. Furthermore, A/G61 polymorphism was not a prognostic factor for survival in GBM patients, although it does appear to affect progression-free survival.
