Author/Authors :
Idbaih، نويسنده , , Ahmed and Boisselier، نويسنده , , Blandine and Marie، نويسنده , , Yannick and El Hallani، نويسنده , , Soufiane and Sanson، نويسنده , , Marc and Crinière، نويسنده , , Emmanuelle and Rodero، نويسنده , , Mathieu and Carpentier، نويسنده , , Catherine and Paris، نويسنده , , Sophie and Laigle-Donadey، نويسنده , , Florence and Ducray، نويسنده , , François and Hoang-Xuan، نويسنده ,
Abstract :
The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72 polymorphism and compared them with a series of 144 healthy controls. Arg/Arg, Arg/Pro, and Pro/Pro genotypes were found in 54.2 versus 60.4%, 39.3 versus 34.0%, and 7.3 versus 5.6% of patients and controls, respectively. This suggests no association between oligodendroglial tumors and the SNP in codon 72 of TP53. Similarly, no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status.
